Atalanta are with out Duvan Zapata, Davide Zappacosta and suspended Teun Koopmeiners, whereas Juventus have Adrien Rabiot again from harm.
It kicks off on the Allianz Juventus Stadium in Turin on Sunday at 19.45 GMT.
La Dea will make the journey with out Koopmeiners, because the Netherlands worldwide sits out a ban resulting from an accumulation of yellow playing cards.
It’s a huge loss, contemplating he has contributed six targets and 4 assists in 18 Serie A video games thus far this season.
Coach Gian Piero Gasperini can be lacking striker Duvan Zapata and wing-back Zappacosta resulting from harm, so Rasmus Hojlund and Ademola Lookman are once more the favourites to begin.
The help is to be chosen between Mario Pasalic and Jeremie Boga.
Luis Muriel will most likely solely be left on the bench to start with after Atalanta thrashed Salernitana 8-2 final week.
Juventus need to postpone the sector points apart and ignore the 15-point penalty to concentrate on the soccer.
The harm listing stays in depth, together with Dusan Vlahovic, Paul Pogba, Leonardo Bonucci, Mattia De Sciglio and Kaio Jorge, however Rabiot is accessible after muscular points.
Federico Chiesa is more likely to be rested initially, after scoring the Coppa Italia winner towards Monza on Thursday, so Angel Di Maria helps Moise Kean.
Juventus: Szczesny; Danilo, Bremer, Alex Sandro; McKennie, Fagioli, Locatelli, Rabiot, Kostic; Di Maria, Kean
Atalanta: Musso; Toloi, Palomino, Scalvini; Hateboer, De Roon, Ederson, Ruggeri; Pasalic; Lookman, Hojlund